Application of Biodegradable PLGA-PEG-PLGA/CPC Composite Bone Cement in the Treatment of Osteoporosis

The aim of this study was to evaluate the biological activity, safety, and effectiveness poly(lactic acid)–poly(glycolic acid)–poly(ethylene glycol)–calcium phosphate cement (PLGA-PEG-PLGA/CPC). Methods: PLGA-PEG-PLGA/CPC composite bone used for interaction with MC3T3-E1 mouse osteoblasts in vitro its compatibility tested using Cell Counting Kit-8 (CCK-8). Alizarin Red staining alkaline phosphatase activity were detect osteogenic properties. Twenty healthy female New Zealand rabbits selected establish osteoporosis models, which randomly divided into two groups. experimental group treated 30 wt.% PLGA-PEG-PLGA/CPC, while control polymethyl methacrylate (PMMA) cement. Imaging histomorphology vertebral body analyzed after 12 weeks. distribution degradation assessed micro-computed tomography examination hematoxylin–eosin (HE) staining. Results: In vitro, CCK-8 revealed significant proliferation showed that degree increased time. Quantitative results absorbance significantly higher than CPC on days 7 14. levels 14 group. vivo, postoperative material evenly distributed a small amount penetrated trabecular bone. After weeks, absorption formation new matrix observed callus obvious. Conclusion: has positive effect treatment osteoporosis.